The 18-chromatin state data, derived using hidden Markov models (HMMs), was obtained for sample E073 in the Epigenome Roadmap project51 (http://egg2.wustl.edu/roadmap/web_portal/chr_state_learning.html). These data were derived from a mixture of DLPFC tissue from two subjects (75 year old and 81 year old). The chromatin states overlapping DMRs, blocks, and meQTL SNPs (by genomic coordinates, chr:start-end) were obtained, and compared to a background of all considered probe groups, collapsed probe groups, and all considered SNPs, respectively. Overlap was assessed based on the total coverage (in base pairs) of the chromatin states. Fold changes for enrichment and depletion > 2 were reported. While the project generated data on two fetal brain samples, processed chromatin state data was currently unavailable. Additional details on the chromatin states are available at the above website.
