and tightly clustered (typically separated by <250 kb), resulting in the frequent presence of multiple associated variants in a locus. The observations that genes and especially pathways are now beginning to be implicated by multiple variants suggests that the larger set of results retain biological specificity but that at some point, a new set of associated variants will largely highlight the same genes, pathways and biological mechanisms as have already been seen. This endpoint (which we have not clearly reached for height) could be considered analogous to reaching “saturation” in model organism mutagenesis screens, where new alleles typically map to previously identified genes21.
