including frontal cortex (r=0.27, FDR=0.018), parietal (r=0.20, FDR=0.016), temporal (r=0.19, FDR=0.022) and neostriatum regions (r=0.28, FDR=3.3e-09) as well as ventricular enlargement (r=0.17, FDR=0.031). Several modules, however, showed correlation to a more restricted type of neuropathology, including the modules characteristic for the glucuronosyl transferase correlated to Braak stage (r=0.18, FDR=9.8e-05), NAD(P) homeostasis to Braak stage (r=0.25, FDR=1.4e-07), neurogenesis to ventricular enlargement (r=0.19, FDR=5.1e-05) and GST to ventricular enlargement (r=0.22, FDR=4e-06). The significance of functional enrichment in modules and the number of neuropathology traits correlated with modules were considered important criteria in rank-ordering modules for their potential to affect LOAD.
