The clinical and genetic data in this study were obtained from the Partners Healthcare System Biobank(Gainer et al., 2016; Karlson et al., 2016). The Partners Biobank is a large integrated database, including high-quality clinical data from 8 Harvard-affiliated hospitals. It includes medical information for ~100,000 patients and matched genomic data for ~25,000 patients. For our genome-phenome association study, we extracted matched genetic and clinical phenotype information for 21,310 European ancestry subjects. All participants signed an informed consent prior to study participation and explicitly allowed identifiable data to be shared with qualified investigators. The study’s protocol was reviewed and approved by Partners Human Research Committee.
