initial GEWIS studies of cancer phenotypes with null findings that have yet to be published. While there have been a small number of initial success stories where consideration of environmental factors or GxE interactions contributed to discovery of novel genetic loci for cancer and other complex diseases [Cornelis, et al. 2012; Hamza, et al. 2011; Hancock, et al. 2012; Manning, et al. 2012; Wu, et al. 2012] publication bias is of substantive concern. The upcoming years may be more successful, as increasingly large studies with rare and common genome-wide genotype data incorporate existing environmental data, improved measures of environmental factors, and novel statistical methods.
