studies in humans as well as non-human primates 16, 37, 57, 58 have repeatedly demonstrated the gain in power that comes from designs that genotype a relatively small number of subjects for functional genetic variation, measure fine-grained, quantitative phenotypic traits, and apply the power of general linear models to test the a priori hypothesis. In this study, we demonstrate that a functional rhCRH promoter variant is associated with relevant intermediate phenotypes in addition to behavioral traits that were assessed at multiple developmental time points and which have been, in both primate and non-primate species, repeatedly and reliably linked to differences in CRH system activity.
