All models (statistical analysis) covaried for: reported biological sex, highest parent educational attainment, parent household income, parent separation between the ages of 12 and 17, AUD case/control family status, parent AUD, birth cohort, and study site (Table 1), following prior work in this cohort (Bucholz et al., 2017). The following analysis-specific covariates were included in relevant models: White, Black, and those endorsing neither (self-reported) and Hispanic/not Hispanic (self-reported) in non-genetic analyses (Table 1); cigarette and cannabis use initiation and dependence in non-genetic analyses; first 10 ancestral principal components in genetic analyses; age of first drink and first intoxication in models analyzing survival from these milestones to adjust for any variability in risk period (Bucholz et al., 2017; Supplemental Methods).
