Chunk #53 — 6.0 How Do Electrophysiological Endophenotypes Compare with Other Quantitative Traits? — 6.1 Are endophenotype effect sizes larger than those of other phenotypes?
Figure 1) to have detected the largest genetic effects, and are thus likely to provide only slightly overestimated effect sizes of these variants. The lone exception is the single antisaccade hit from our work, which we expect to be significantly overestimated. We did not include case-control results (e.g., schizophrenia, macular degeneration, etc.) because effects for binary phenotypes are estimated on different scales such as odds ratios and are not easily directly compared to quantitative effect metrics such as r-squared. As electrophysiological endophenotypes are frequently quantitative, we believed comparisons with other quantitative phenotypes was most appropriate.
