being an appreciable phenotypic focal point within the network that is distinct from the other two coding isoforms of SCN4B. Differentially spliced transcripts expressed alongside NM_001142349 included NM_014191 (SCN8A) (Fig. S7), a sodium channel alpha subunit expressed within cortical nodes of Ranvier, dendrites, and neuronal synapses 59. Positive coexpression of SCN8A and SCN4B isoforms, plus additional transcripts, within alcoholic PFC denotes a specific functional component influencing the neuronal circuitry of lifetime alcohol consumption.