paperKB
coga / coga-kb
Processing
Help
Sign in

Chunk #21 — RESULTS — Potential role of SCN4B transcripts in lifetime human alcohol consumption

Source
Transcriptome organization for chronic alcohol abuse in human brain.
Embedded
yes

Text

being an appreciable phenotypic focal point within the network that is distinct from the other two coding isoforms of SCN4B. Differentially spliced transcripts expressed alongside NM_001142349 included NM_014191 (SCN8A) (Fig. S7), a sodium channel alpha subunit expressed within cortical nodes of Ranvier, dendrites, and neuronal synapses 59. Positive coexpression of SCN8A and SCN4B isoforms, plus additional transcripts, within alcoholic PFC denotes a specific functional component influencing the neuronal circuitry of lifetime alcohol consumption.