The nicotine-related behavioral, electrophysiological, and neurochemical effects of PPAR-α agonists in the present study are similar to the effects obtained earlier with the FAAH inhibitor URB597 (7,9). The results obtained here with the PPAR-α agonist WY14643 are also consistent with the finding that URB597 does not alter nicotine discrimination (36). All of these findings converge to suggest that URB597 modulates the rewarding effects of nicotine by increasing levels of the endogenous PPAR-α ligands OEA and PEA, rather than by increasing the endocannabinoid anandamide.
