TADA de novo algorithm to assess the per gene q values. We then recorded the number of pTD genes (q < 0.3) and hcTD genes (q < 0.1) observed at each cohort size (Figure 5C). Based on the smoothed curves, the predicted number of probable genes for the cohort presented in this study (484 trios) tracked very closely with our empirical results: we predict 2.8 pTD genes (we observed 3) and 0.69 hcTD genes (we observed 1). Moreover, we can further predict that, at 1,000 trios, we will identify approximately 11.8 pTD genes and 3.2 hcTD genes and, at 2,000 trios, will identify 39.8 pTD genes and 13.4 hcTD genes.
