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Chunk #11 — Materials and Methods — Real datasets — Creating validation haplotypes

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A general approach for haplotype phasing across the full spectrum of relatedness.
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We phased the pedigrees in each cohort using Merlin (version 1.1.2), which produces the most likely haplotypes given the pedigree structure using the Lander-Green algorithm. The phasing occurs one pedigree at a time and no information is shared between pedigrees. These haplotypes should be highly accurate and hence suitable for validation purposes. The accuracy of the haplotypes will increase with pedigree size, so in some of our experiments we only use those haplotypes from larger pedigrees.