and is conserved across species. This interpretation must be tempered by the fact that the power to rule out this SNP is reduced due to the considerable allele frequency difference in the EA versus AA samples. With a larger sample size, better discrimination among the remaining SNPs might have been possible. Nevertheless, in the available data our approach has narrowed the field of candidate variants for functional follow-up. Indeed, our recent work has now shown that rs16969968 alters receptor function in vitro [11].
