Noteworthy co-localizing independent signals occurred at three regions (Supplementary Table 5): one region with a genome-wide significant association at 10q24.32-q24.33 (Table 2), a second region that nearly met this threshold at MAD1L1 (encoding mitotic arrest deficient-like 1; rs10226475, P = 5.06 × 10−8; Supplementary Table 4) and a third region at CACNA1C (encoding calcium channel, voltage-dependent, L type, α 1C subunit), the latter of which has previously been associated with bipolar disorder10 and other psychiatric phenotypes including schizophrenia11. The conditionally independent signal at CACNA1C was more significant than any observation made in 100 permutations of the entire experiment (both conditional P < 10−5) and supports CACNA1C in schizophrenia after genome-wide correction (P < 0.01), even without considering these prior reports.
