All SNPs were in Hardy-Weinbnerg equilibrium (Table 2). Minor allele frequencies varied by race, with African Americans less likely than whites to carry the minor alleles at any of the three SNPs (Table 2). In a log-additive model, risk of NSCLC associated with any of the SNPs among whites was increased by 20–25%, when adjusting for age, sex, and ever smoking (Table 3). However, after adjusting for cigarettes smoked per day or pack-years, risk estimates in whites were reduced and were no longer statistically significant. Among African Americans, risk was not significantly associated with rs8034191. In African Americans, significantly increased risk was associated with rs931794 (odds ratio [OR] 1.41; 95% confidence interval [CI] 1.10 –1.81) and rs1051730 (OR 1.66; 95% CI 1.20–2.30) after adjusting for age, sex, and ever smoking. Risk remained unchanged and significantly elevated among African Americans when adjustment was made for cigarettes smoked per day for rs931794 and rs1051730. None of the SNPs were associated with lung cancer among never smokers (Table 4). In the subset of ever smokers, ORs associated with risk of lung cancer were
