methylation differences are likely consistent with those expected from a model of epigenetic cross-generational transmission, and are comparable to what has been observed by epigenome-wide association studies in complex traits (De Jager PL, 2014; Huynh et al, 2014; Pidsley et al, 2014). For example, alterations in DNA methylation at the human IGF2 locus have been associated with periconceptional famine and shown to persist into adulthood, with levels differing by only ~5% on average between famine-exposed and unexposed individuals (Heijmans et al, 2008).
