profile data from the temperament and character inventory (TCI).19, 20, 21 To examine the mRNA expression levels of the METTL21A (FAM119A) and CREB1 genes, 100 post-mortem human brain specimens, from which DNA and RNA were extracted for experimental use, were obtained from the Stanley Medical Research Institute (SMRI; Bethesda, MD, USA) as samples independent of those in the association study with opioid sensitivity (SMRI samples).
