LD score regression has been used to show genetic correlation between multiple psychiatric phenotypes (Bulik-Sullivan et al., 2015a), which included observed positive genetic correlation between age of onset of smoking and cigarettes per day (p<0.05). However, to our knowledge, the genetic correlation between the full complement of smoking behaviors (including nicotine dependence) and schizophrenia has not been fully characterized. In this study, we use LD score regression to evaluate the genetic correlation between multiple smoking phenotypes and schizophrenia.
