For cQTLs, no established methods exist for large-scale data, although there have been previous efforts (37, 38). To identify cQTLs, we focused on our reference set of enhancers and examined how H3K27ac activity varied at these loci across 292 individuals (Fig. 4C) (21). Overall, we identified ~2000 cQTLs in addition to 6200 identified from individuals within the CMC cohort (39).
