Serotonin and antidepressants are key regulators of anxiety and mood. Since both serotonin and imipramine increased the inhibitory phosphorylation of FoxO1 and FoxO3a in mouse brain, we hypothesized that mice lacking brain FoxOs may exhibit an anxiolytic or antidepressive behavioral phenotype. To test this hypothesis, we examined behavioral phenotypes of brain FoxO1-knockout and systemic FoxO3a-deficient mice.
