Sequenom genotyping of variants in the probands and their family members was performed on the iPLEX Gold platform at the Broad Institute. Variants were genotyped in control individuals also using the Sequenom iPLEX Gold assay at the Molecular Genetics Core Facility at Children's Hospital Boston. The controls collection consisted of 704 neurologically normal samples obtained from the Coriell Cell Repositories (Camden, NJ; 584 Caucasian samples), or available in our lab (80 Saudi and 40 Bedouin samples).
