To investigate the role of KCNJ6 gene variants in neuronal function and ethanol response we selected eight subjects of European ancestry from the COGA cell repository, with contrasting KCNJ6 SNPs and the presence or absence of alcohol dependence (Table 1). Since multiple SNP genotypes were used, we label groups as AUD “affected” (AF) or “unaffected” (UF) for simplicity, since in this set of subjects diagnosis correlates with SNP haplotype. However, the focus of this study is the KCNJ6 haplotype.
