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Chunk #17 — Subjects and Methods — Statistical analysis — Local ancestry estimation in AAs

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Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans.
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phased YRI and CEU data, 188 SNPs that were located at the NRG1 gene and were genotyped in both the SAGE AA sample and in the subset of the replication AA sample (931), were used to estimate local ancestry at the NRG1 locus. The estimated average European ancestries at the NRG1 locus were 0.194 and 0.171 for the SAGE and the replication AA samples, respectively, which approximated the values of the global European ancestry proportion in each sample.