There are a number of statistical considerations that influence the detection and interpretation of cGxE that have not received widespread attention in the literature. We highlight some of the most critical issues next, and many of our concerns are consistent with those of others who’ve recently written on this topic (e.g., Roisman et al., 2012; Zammit, Lewis, Dalman, & Allebeck, 2010; Zammit, Owen, & Lewis, 2010).
