Chunk #16 — Methods

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A genome-wide association study reveals variants in ARL15 that influence adiponectin levels.

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We undertook a GWAS to detect SNPs which were associated with adiponectin, and tested the physiologic and clinical relevance of these SNPs by assessing their association with indices of glucose homeostasis and BMI in European populations, and with T2D and CHD in large clinical cohorts (Figure 1).