Twenty-four of the genes identified by our study were previously identified by GWAS (Supplemental Table S2, GWAS column). This list includes several genes with large fold changes, such as SLC39A10 (a zinc transporter), suppression of tumorigenicity 18 (ST18), protein tyrosine phosphatase receptor type D (PTPRD), BCL2-associated athanogene 3 (BAG3), and von Willebrand factor (VWF). Although these genes might not be thought of as related to alcoholism, their differential expression in alcoholic brains, together with their genetic connection, suggests they might be. The IPA analysis of the 107 genes in our study that were identified in other studies indicated that 38 of these genes are related to cell death, including ST18 and BAG3.
