transcripts 1 and 2 in Figure 4). For instance, transcripts 2 and 3 in Figure 4 differ in the 3' splice site used in the second intron, yielding an SJD value of 2/4 = 0.5, whereas transcripts 2 and 4 differ by skipping/inclusion of an alternative exon, which affects a larger fraction of the introns in the two transcripts and therefore yields a higher SJD value of 3/5 = 0.6.