At an FDR≤ 0.10, 68 miRNA cis-eQTLs were detected; the most significant cis-eQTLs were detected for hsa-miR-134-5p (p = 7.1x10-5) and -370-3p (p = 8.2x10-5) (Fig 6A and 6B). We also identified many instances of single variants associated with the expression of multiple miRNAs. This is not surprising in that many miRNAs are clustered genomically (within 10kb), and being expressed on the same primary transcript, will show similar regulatory patterns [56]. The full list of the identified eQTLs for the miRNA hub genes is given in S8 Table.
