in somatic nuclei transplanted to Xenopus oocytes [36]. Although reprogramming to induced pluripotency may be mechanistically different, the chromatin remodelling enzyme Chd1 has been shown to be important for the induction and maintenance of pluripotency by promoting an open chromatin state [37]. Chromatin remodellers Brg1 and Baf155 have been found to increase the efficiency of Oct4-GFP reactivation during induction of pluripotency from mouse embryonic fibroblasts (MEFs) [38], in addition to egg extract work [39].
