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Chunk #26 — 2 Animal Models for Compulsive Alcohol Seeking

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Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorder.
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High doses of alcohol solution will be self-administered intragastrically after animals are made dependent via passive intragastric infusion, and rats will self-infuse 4–7 g/kg per day of ethanol (Fidler et al. 2006). Here, blood alcohol levels average 0.12 g%, measured 30 min after the start of a bout in which rats infuse 1.5 g/kg per 30 min.