Criteria for DNA samples were call rate >97%; non-outlier for mean heterozygosity across all SNPs and for ancestry principal component scores (EIGENSTRAT24); pairwise identity-by-descent estimates not >0.1 with many other samples (pairs of apparent relatives were also inspected and one retained); and non-ambiguous heterozygosity values for X chromosome SNPs in females (these samples were excluded only for X chromosome analyses if they passed autosomal QC). Additional details about population substructure analyses are provided in online Supplementary Methods. Further analyses included 1,020 cases and 1,636 controls.
