Chunk #20 — Identifying Specific Genes Related to AOD Dependence — Genes Encoding Proteins Involved in Neurotransmission — Genes Encoding the GABAA Receptor
Several other GABAA receptor genes have yielded more modest evidence of association with different aspects of AOD dependence. Thus, GABRB3 (Noble et al. 1998) and GABRG3 (Dick et al. 2004) are modestly associated with alcohol dependence, GABRA1 (Dick et al. 2006b) is associated with alcohol-related phenotypes (e.g., history of alcohol-induced blackouts and age at first drunkenness), and GABRG2 (Loh et al. 2007) is associated with aspects of drug dependence. These findings await confirmation in independent samples.
