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Chunk #11 — 3. Impact of spatial scale on CSD implementations

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Generator localization by current source density (CSD): implications of volume conduction and field closure at intracranial and scalp resolutions.
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By virtue of Eq. 4, CSD methods have been widely applied to identify and measure the current generators underlying the local field potential (LFP) of intracranial recordings (LFP depth profile). For the same reason, CSD methods have been successful for revealing neuronal current generators underlying EEG scalp topographies. Although a similar computational approach is used, the vast differences in scale make the implementations quite distinctive. In view of the history of the approach and the intuitive correspondence between the neuronal generators and the computed CSD, we will first explore the development and implementation of multicontact intracranial methods specialized for measuring LFPs in laminated tissue (e.g., cortical structures). The application of these methods to EEG scalp topographies will then be described in the context of the volume conduction model.