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Chunk #15 — SUCCESSES IN IDENTIFYING VARIANTS RELATED TO COMPLEX DISEASES

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The HapMap and genome-wide association studies in diagnosis and therapy.
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The pace of genomic discovery increased dramatically in 2007, following the increased availability of high-density genotyping platforms and experience in interpreting the results. Simultaneous publication of coordinated efforts in multiple diseases, and of the WTCCC study, have been described above. Rapid progress has continued into 2008 with identification of > 150 loci for > 60 common diseases and traits (Figure 1). Indeed, as Hunter & Kraft have noted, “There have been few, if any, similar bursts of discovery in the history of medical research” (45).