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Chunk #0 — Introduction

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Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence.
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Cigarette smoking is a leading cause of preventable death, resulting annually in nearly 6 million premature deaths worldwide.1 Smoking-related deaths are most often attributed to increased rates of cancer, cardiovascular disease, and chronic obstructive pulmonary disease (COPD).2 Despite the well-known adverse health effects, an estimated 45.3 million U.S. adults smoke cigarettes, of whom over 68% report wanting to quit.3, 4