It is unknown what particular behaviors may be causally linked to disturbances of striatal neurons expressing the molecular abnormalities currently detected in the adult dorsal striatum. It is clear that the parental history of THC did not induce a general gross impairment of motor behavior in either sex, but was quite specific to novelty reactivity in females. Within the dorsal striatum, the medial subregion is a crucial component of the prefrontal cortex-striatal circuit known to modulate novelty reactivity and integrate cognition and motor behaviors (Rinaldi et al., 2010). As such, specifically investigating the dorsomedial subregion of the striatum may provide some insight into the sex-specific differences observed in novelty seeking behavior.
