involved in emotional regulation and impulsivity, showed decreased right/left volumes in high-risk offspring in comparison with control subjects. Findings also demonstrated relationships between OFC volumes and genetic and self-report information. Specifically, lower right volume was significantly associated with variation in the serotonin transporter (5-HTT) and brain-derived neurotrophic factor (BDNF) genes, and white matter ratios were positively correlated with a self-report measure of self-control from the Multi-dimensional Personality Questionnaire (MPQ; Tellegen & Waller, 1992), demonstrating that reduced OFC white matter is related to self-control aspects of impulsivity (i.e. urgency). These two studies provide limited evidence for a biological association between impulsive tendencies and alcohol consumption.
