We thus now report data that confirms the overlapping areas of Baltimore from which ECA and MNB subjects were sampled. We report genome wide association studies for substance dependence phenotypes for Baltimore ECA subjects. We compare these genome wide association results with those from ethnically-matched MNB research volunteers who were recruited from many of the same areas. We discuss the significance of the substantially-overlapping data that we report, as well as the limitations of the samples and datasets. These data document large molecular genetic overlaps between probability-sample and research volunteer samples for substance dependence.