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Chunk #7 — INTRODUCTION

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Relationships between impulsivity and subjective response in an IV ethanol paradigm.
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Given the lack of clear prior findings, continued research on the relationship between the constructs of impulsivity and subjective effects of alcohol is of high clinical importance. The present report is a secondary analysis of data from a study designed to compare the effects of two ethanol doses and placebo on subjective response to ethanol and cognitive function in non-alcohol-dependent, family history positive versus negative young adults (Kerfoot et al. 2013). In the parent study, participants responded to IV ethanol administration with clamping technique in a dose-related, time-dependent manner on measures of subjective effects and showed impaired coordination and impaired performance on cognitive measures. However, no significant differences were found between family history positive and negative individuals. To our knowledge, among studies examining relationships between impulsivity and subjective response, ours is the first to utilize data from IV administration and the first involving multiple alcohol doses. Use of multiple doses is important as dosage is a key factor in subjective response (Morean and Corbin 2010; Schuckit et al. 1984). The use of lower risk social drinkers allows for investigation of