trigger very different transcriptional responses. Genes predicted to be cortisol-responsive disproportionately encode receptors and other molecules involved in a cell’s “perception” of its local environment. In contrast, putative catecholamine-responsive genes include few receptors, but a high concentration of signal transduction molecules and transcription factors involved in cellular “decision-making” (converting receptor-mediated perception into changes in gene expression and cellular behavior). Thus, severe, overwhelming stress may trigger a cellular form of “denial” (altering perception), whereas active-coping challenges induce something more akin to “sublimation” (altering responses to perceptions).
