Our 601 distant eQTLs with q<0.001 (Figure 5) involved 581 genes and 538 non-redundant SNPs (for each gene, only the most significant SNP per chromosome was retained). We applied additional QC to these highly significant distant eQTLs (Supplementary Note), reducing the number of eQTLs to 348 (57.9%), of which 165 (47.4%) replicated in NESDA (q<0.01) (Figure 5, Supplementary Figure 6 and Supplementary Table 6). Genes in the 348 eQTLs were analyzed using DAVID P-values for KEGG and GO enrichment, which have been shown to be liberal53, but only GO: 0003779 (actin binding) was declared significant (P= 0.0001, FDR q=0.046).
