Similar to the idea behind disease-related gene databases is the Human Variome Project (15) that aims to develop novel methods of cataloging human genetic variation and its relation to disease, and like gene databases the results of this project could be incorporated directly into SPOT. As next generation sequencing becomes the standard in following up on GWAS, the discovery and analysis of numerous and possibly very important rare variants (16) may require biological prioritization to design follow-up studies, and we will be studying ways of modifying SPOT to deal with this challenging problem.
