Figure S1 shows that laser stimulation of cells in the NAcore infected with control virus or fibers in the NAcore following PL infection had no effect on cocaine alone or cocaine + cue-reinstated cocaine seeking, indicating that heating from the continuous laser light did not affect cocaine-seeking behavior. Figure S2 shows that optical inhibition of the NAcore, as in Fig. 1B, did not affect open-field behavior or cocaine-induced locomotor activity, suggesting the lack of these manipulations on nonspecific motor behavior. Inactive lever presses were not affected by laser stimulation in either the PL or NAcore groups (data not shown).
