A study by Levran et al. [85] analyzed 15 SNPs in the NGFB gene and their association with treatment with methadone. The study reported that the average daily methadone doses were significantly lower in subjects homozygous for the A allele of SNP rs2239622 (81.7 mg) than heterozygous or non-carrier subjects (153 and 140 mg, respectively) [85]. Therefore this study provides an evidence for an association between NGFB and methadone dose.
