The PheWAS analyses identified associations with medical phenotypes in EUR. With increasing number of AFR GWAS now published, mainly from MVP, we were able to estimate genetic correlations between AUD and a limited set of traits in AFR. As in EUR, AUD in AFR was genetically correlated with substance use traits including OUD, smoking trajectory (that identifies groups of individuals that follow a similar progression of smoking behavior), and maximum habitual alcohol intake. PheWAS of PRS in AFR from PsycheMERGE and Yale–Penn confirmed that AUD is genetically correlated with substance use traits. The lack of a wider set of phenotypes for comparison by ancestry is a continuing limitation.
