Chunk #113 — Online Methods — Inference of point mutation multiplicity

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Absolute quantification of somatic DNA alterations in human cancer.

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For the computations in this study we fixed λ = 25, wsq to 0.25, and wSc to 0.75, which produced a fit to the combined-sample mutation-fraction distribution (Fig. 4b). The results presented in Fig. 4 were robust to various settings.