In conclusion, this study has demonstrated that COVID-19-related stressors were associated with increased drunkenness frequency among COGA participants with a lifetime history of AUD, suggesting that they may be especially vulnerable to some stressors. Furthermore, this study revealed important gender differences in vulnerability to COVID-19-related stressors among those with a history of AUD. Perceived stress, essential worker status, media consumption, social disconnection, and relationship quality are specific areas of focus for designing intervention and prevention strategies aimed at reducing pandemic-related substance abuse.