The greater resolution of height associated variants provided by increased sample size, combined with improved gene prioritization and gene set enrichment approaches, identified multiple new tissues, gene sets and specific genes that are highly likely to be involved in the biology of skeletal growth. Specifically, using a variety of established and novel pathway methods, we identified ~3 times as many enriched pathways and prioritized ~5 times as many genes (including genes newly prioritized in previously identified loci) compared to results derived from identical pathway methods to the previous GWAS of 133,000 individuals (Table 2).
