Second, the findings allow us to refute the hypothesis that ADHD is purely a social construct, which has important clinical and social implications for affected children and their families. Finally, although the number of children with intellectual disability in our sample is small, more than a third carried a large, rare CNV. None of these participants had been assessed for this type of mutation by clinical services. Microarray-based comp-arative genomic hybridisation enables the accurate detection of submicroscopic CNVs and is increasingly being used to investigate patients with intellectual disability or congenital abnormalities in some clinical settings. Our results suggest that routine referral to clinical geneticists and screening for such mutations could be helpful for children with ADHD and intellectual disability.
