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Chunk #37 — Methods — Analysis — LDSC analysis

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Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases.
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We performed the partition heritability analyses for functional annotation using the LDSC program. We obtained the weights for the multi-cell and tissue chromatin marks and performed the LDSC partition heritability analyses on munged summary statistics of AUD and DPW GWAS21. We specifically followed the default parameters to perform the LDSC analyses as listed in the tutorial for partition heritability analysis (https://github.com/bulik/ldsc/wiki/Partitioned-Heritability).